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Detomasi TC, Batka AE, Valastyan JS, Hydorn MA, Craik CS, Bassler BL, Marletta MA. Proteases influence colony aggregation behavior in Vibrio cholerae. JBC, 2023


Wittenborn EC, Thomas WC, Houghton KA, Wirachman ES, Wu Y, Marletta MA. Role of the Coiled-Coil Domain in Allosteric Activity Regulation in Soluble Guanylate Cyclase. Biochemistry, 2023

Martinez-D'Alto A, Yan X, Detomasi TC, Sayler RI, Thomas WC, Talbot NJ, Marletta MA. 

Characterization of a unique polysaccharide monooxygenase from the plant pathogen Magnaporthe oryzae.

PNAS, 2023

Detomasi TC, Rico-Ramirez AM, Sayler RI, Goncalves AP, Marletta MA, Glass NL.

A moonlighting function of a chitin polysaccharide monooxygenase, CWR-a, in Neurospora crassa allorecognition.

eLife, 2022

Reyes-Rivera J, Wu Y, Guthrie BGH, Marletta MA, King N, Brunet T.

Nitric Oxide Signaling Controls Collective Contractions in a Colonial Choanoflagellate.

Curr. Biol., 2022 

Lemon CM, Hanley D, Batka AE, Marletta MA.

Ratiometric Oxygen Sensing with H-NOX Protein Conjugates.

Inorg. Chem., 2022

Lemon CM, Nisley AJ, Latorraca NR, Wittenborn EC, Marletta MA.

Corrole-protein Interactions in H-NOX and HasA.

RSC Chem. Biol., 2022

Lemon CM and Marletta MA.

Designer Heme Proteins: Achieving Novel Function with Abiological Heme Analogues.

Acc. Chem. Res., 2021

Marletta MA.

Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going?

Biochem, 2021

Wittenborn EC and Marletta MA.

Structural Perspectives on the Mechanism of Soluble Guanylate Cyclase Activation.

Int. J. Mol. Sci., 2021

Lemon CM and Marletta MA.

Corrole-substituted fluorescent heme proteins.

Inorg. Chem. 2021

Hangasky JA, Detomasi TC, Lemon CM, Marletta MA.

Glycosidic Bond Oxidation: The Structure, Function, and Mechanism of Polysaccharide Monooxygenases.

In Comprehensive Natural Products III; Liu, H. W.; Begley, T. P., Eds.; Elsevier: Amsterdam, 2020; Vol. 5; pp 298–331.

Thompson MG, Blake-Hedges JM, Pereira JH, Hangasky JA, Belcher MS, Moore WM, Barajas JF, Cruz-Morales P, Washington LJ, Haushalter RW, Eiben CB, Liu Y, Skyrud W, Benites VT, Barnum TP, Baidoo EEK, Scheller HV, Marletta MA, Shih PM, Adams PD, Keasling JD.

An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism.

Nat. Comm., 2020

Horst BG, Yokom AL, Rosenberg DJ, Morris KL, Hammel M, Hurley JH, Marletta MA.

Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.

eLife, 2019

Vu VV, Hangasky JA, Detomasi TC, Henry SJW, Ngo ST. Span EA, Marletta MA.

Substrate selectivity in starch polysaccharide monooxygenases

JBC, 2019

Goncalves AP, Heller J, Span EA, Rosenfield G, Do HP, Palma-Guerrero J, Requena N, Marletta MA, Glass NL.

Allorecognition upon fungal cell-cell contact determines social cooperation and impacts the acquisition of multicellularity

Current Biology, 2019

Horst BG, Stewart EM, Nazarian AA, Marletta MA.

Characterization of a carbon monoxide-activated soluble guanylate cyclase from Chlamydomonas reinhardtii.

Biochemistry, 2019

Hangasky JA, Detomasi TC, Marletta MA.

Glycosidic bond hydroxylation by polysaccharide monooxygenases.

Trends in Chemistry 2019

Guo Y and Marletta MA.

Structural insight into H-NOX gas sensing and cognate signaling protein regulation.

ChemBioChem 2019

Guo Y, Cooper MM, Bromberg R, Marletta MA.

A dual H-NOX signaling system in Saccharophagus degradans.

Biochemistry 2018

Hespen CWBruegger JJ, Guo Y, Marletta MA.

Native alanine substitution in the glycine hinge modulates conformational flexibility of Heme Nitric oxide/Oxygen (H-NOX) sensing proteins.

ACS Chem. Bio. 2018

Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA.

Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes.

JBC 2018, 293, 6282-6296.

Hangasky JA and Marletta MA.

A random-sequential kinetic mechanism for polysaccharide monooxygenases.

Biochemistry 2018​

Hangasky JA, Iavorone AT, Marletta MA.

Reactivity of O2 versus H2O2 with polysaccharide monooxygenases.

Proc Natl Acad Sci 2018

Horst BG and Marletta MA.

Physiological activation and deactivation of soluble guanylate cyclase.

Nitric Oxide, 2018, 77, 65–74

Guo Y, Iavarone AT, Cooper MM, Marletta MA.

Mapping the H-NOX/HK Binding Interface in Vibrio cholerae by Hydrogen/Deuterium Exchange Mass Spectrometry. Biochemistry. 2018


Guo Y, Suess DLM, Herzik MA, Iavarone AT, Britt RD, Marletta MA.

Regulation of nitric oxide signaling by formation of a distal receptor–ligand complex.

Nat Chem Biol. 2017

Agostoni M, Hangasky JA, Marletta MA.

Physiological and molecular understanding of bacterial polysaccharide monooxygenases.

MMBR 81 2017.

Rao M, Herzik MA, Iavarone AT, Marletta MA.

Nitric oxide-induced conformational changes govern H-NOX and histidine kinase interaction and regulation in Shewanella oneidensis.

Biochemistry. 2017, 56 (9), 1274–1284

Span E, Suess DLM, Deller MC, Britt RD, Marletta MA.

The role of the secondary coordination sphere in a fungal polysaccharide monooxygenase.

ACS Chem Biol. 2017

Hespen CWBruegger JJPhillips-Piro CMMarletta MA.

Structural and Functional Evidence Indicates Selective Oxygen Signaling in Caldanaerobacter subterraneus H-NOX.

ACS Chem Biol. 2016 Jun 21.

Vu VV and Marletta MA.

Starch-degrading polysaccharide monooxygenases.

Cell Mol Life Sci. 2016; 73, 2809-19. doi: 10.1007/s00018-016-2251-9.

Span EA and Marletta MA. 

The framework of polysaccharide monooxygenase structure and chemistry. 

Curr Opin Struct Biol. 2015; 35, 93-99. doi: 10.1016/


Sürmeli NB, Müskens FM, Marletta MA.

The Influence of Nitric Oxide on Soluble Guanylate Cyclase Regulation by Nucleotides: Role of the Pseudosymmetric Site.

J Biol Chem. 2015; 290, 15570-15580. doi: 10.1074/jbc.M115.641431.


Beeson WT, Vu VV, Span EA, Phillips CM, Marletta MA.

Cellulose degradation by polysaccharide monooxygenases.

Annu Rev Biochem. 2015; 84, 923-946. doi: 10.1146/annurev-biochem-060614-034439.


Rao M, Smith BC, Marletta MA.

Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B.

MBio. 2015; 6, e00206-00215. doi: 10.1128/mBio.00206-15.


Wilkins MR, Aldashev AA, Wharton J, Rhodes CJ, Vandrovcova J, Kasperaviciute D, Bhosle SG, Mueller M, Geschka S, Rison S, Kojonazarov B, Morrell NW, Neidhardt I, Surmeli NB, Aitman TJ, Stasch JP, Behrends S, Marletta MA.

α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.

Circ Cardiovasc Genet. 2014; 7, 920-929. doi: 10.1161/CIRCGENETICS.114.000763.


Herzik MA Jr, Jonnalagadda R, Kuriyan J, Marletta MA.
Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins.

Proc Natl Acad Sci USA. 2014; 111, E4156-4164. doi: 10.1073/pnas.1416936111.


Vu VV, Beeson WT, Span EA, Farquhar ER, Marletta MA.
A family of starch-active polysaccharide monooxygenases.
Proc Natl Acad Sci USA. 2014; 111, 13822-13827. doi: 10.1073/pnas.1408090111.


Campbell MG, Smith BC, Potter CS, Carragher B, Marletta MA.
Molecular architecture of mammalian nitric oxide synthases.
Proc Natl Acad Sci USA. 2014; 111, E3614-3623. doi: 10.1073/pnas.1413763111.


Underbakke ES, Iavarone AT, Chalmers MJ, Pascal BD, Novick S, Griffin PR, Marletta MA.
Nitric oxide-induced conformational changes in soluble guanylate cyclase.
Structure. 2014; 22, 602-611. doi: 10.1016/j.str.2014.01.008.


Nierth A, Marletta MA.
Direct meso-alkynylation of metalloporphyrins through gold catalysis for hemoprotein engineering.
Angew Chem Int Ed Engl. 2014; 53, 2611-2614. doi: 10.1002/anie.201310145.


Campbell MG, Underbakke ES, Potter CS, Carragher B, Marletta MA.
Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclase.
Proc Natl Acad Sci USA. 2014; 111, 2960-2965. doi: 10.1073/pnas.1400711111.


Vu VV, Beeson WT, Phillips CM, Cate JH, Marletta MA.
Determinants of regioselective hydroxylation in the fungal polysaccharide monooxygenases.
J Am Chem Soc. 2014; 136, 562-565. doi: 10.1021/ja409384b.


Plate L, Marletta MA.
Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network.
Proc Natl Acad Sci USA. 2013, 110, E4648-4657. doi: 10.1073/pnas.1318128110.


Plate L, Marletta MA.
Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior.
Trends Biochem Sci. 2013, 38, 566-575. doi: 10.1016/j.tibs.2013.08.008.


Weinert EE, Phillips-Piro CM, Marletta MA.
Porphyrin π-stacking in a heme protein scaffold tunes gas ligand affinity.
J Inorg Biochem. 2013, 127, 7-12. doi: 10.1016/j.jinorgbio.2013.06.004.


Smith BC, Underbakke ES, Kulp DW, Schief WR, Marletta MA.
Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation.
Proc Natl Acad Sci USA. 2013, 110, E3577-3586. doi: 10.1073/pnas.1313331110.


Ivanisevic J, Zhu ZJ, Plate L, Tautenhahn R, Chen S, O'Brien PJ, Johnson CH, Marletta MA, Patti GJ, Siuzdak G.
Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism.
Anal Chem. 2013, 85, 6876-6884. doi: 10.1021/ac401140h.


Underbakke ES, Iavarone AT, Marletta MA.
Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase.
Proc Natl Acad Sci USA. 2013, 110, 6777-6782.


Winter MB, Klemm PJ, Phillips-Piro CM, Raymond KN, Marletta MA.
Porphyrin-substituted H-NOX proteins as high-relaxivity MRI contrast agents.
Inorg Chem. 2013, 52, 2277-2279. doi: 10.1021/ic302685h.


Winter MB, Woodward JJ, Marletta MA.
An Escherichia coli expression-based approach for porphyrin substitution in heme proteins.
Methods Mol Biol. 2013, 987, 95-106. doi: 10.1007/978-1-62703-321-3_8.


Fernhoff NB, Derbyshire ER, Underbakke ES, Marletta MA.
Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide.
J Biol Chem. 2012, 287, 43053-43062.


Smith BC, Marletta MA.
Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling.
Curr Opin Chem Biol. 2012, 16, 498-506.


Gunn A, Derbyshire ER, Marletta MA, Britt RD.
Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR).
Biochemistry. 2012, 51, 8384-8390. doi: 10.1021/bi300831m.


Li X, Beeson WT 4th, Phillips CM, Marletta MA, Cate JH.
Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases.
Structure. 2012, 20, 1051-1061.


Plate L, Marletta MA.
Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network.
Mol Cell. 2012, 46, 449-460.


Surmeli NB, Marletta MA.
Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.
Chembiochem. 2012, 13, 977-981.

Derbyshire ER, Marletta MA.
Structure and regulation of soluble guanylate cyclase.
Annu Rev Biochem. 2012, 81, 533-559.


Smith BC, Fernhoff NB, Marletta MA.
Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation.
Biochemistry. 2012, 51, 1028-1040.

Beeson WT, Phillips CM, Cate JH, Marletta MA.
Oxidative cleavage of cellulose by fungal copper-dependent polysaccharide monooxygenases.
J Am Chem Soc. 2012, 134, 890-892.


Phillips CM, Beeson WT, Cate JH, Marletta MA.
Cellobiose dehydrogenase and a copper-dependent polysaccharide monooxygenase potentiate cellulose degradation by Neurospora crassa.
ACS Chem Biol. 2011, 6, 1399–1406.


Winter MB, Herzik MA Jr, Kuriyan J,Marletta MA.
Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain
Proc Natl Acad Sci. USA. 2011, 108, E881-889.


Barglow KT, Knutson CG, Wishnok JS, Tannenbaum SR,Marletta MA.
Site-specific and redox-controlled S-nitrosation of thioredoxin
Proc Natl Acad Sci USA. 2011, 108, E600-606.


Phillips CM, Iavarone AT, Marletta MA.
A quantitative proteomic approach for cellulose degradation by Neurospora crassa.
J Proteome Res. 2011, 10, 4177-4185.


Weinert EE, Phillips-Piro CM, Tran R, Mathies RA, Marletta MA.
Controlling Conformational Flexibility of an O2-binding H-NOX Domain.
Biochemistry. 2011, 50, 6832–6840.


Tran R, Weinert EE, Boon EM, Mathies RA, Marletta MA.
Determinants of the Heme-CO Vibrational Modes in the H-NOX Family.
Biochemistry. 2011, 50, 6519-6530.


Derbyshire ER, Winter MB, Ibrahim M, Deng S, Spiro TG, Marletta MA.

Probing domain interactions in soluble guanylate cyclase.
Biochemistry. 2011, 50, 4281-4290.


Beeson WT 4th, Iavarone AT, Hausmann CD, Cate JH, Marletta MA.

Extracellular aldonolactonase from Myceliophthora thermophila.
Appl Environ Microbiol. 2010, 77, 650-656.


Marletta MA, Fontecave M.

From metals to radicals to light to loops: regulating complex reactions.
Curr Opin Struct Biol. 2010, 20, 657-658.


Sun J, Phillips CM, Anderson CT, Beeson WT, Marletta MA, Glass NL.

Expression and characterization of the Neurospora crassa endoglucanase GH5-1.
Prot Expr Purif. 2011, 75, 147-154.


Olea C, Kuriyan J, Marletta MA.

Modulating heme redox potential through protein-induced porphyrin distortion.
J Am Chem Soc. 2010, 132, 12794-12795.


Stoll S, NejatyJahromy Y, Woodward JJ, Ozarowski A, Marletta MA, Britt RD.

Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state.
J Am Chem Soc. 2010, 132, 11812-11823.


Carlson HK, Vance RE, Marletta MA.

H-NOX regulation of c-di-GMP metabolism and biofilm formation in Legionella pneumophila.
Mol Microbiol. 2010, 77, 930-942.


Yoon J, Herzik MA Jr., Winter MB, Tran R, Olea C Jr., Marletta MA.

Structure and properties of a bis-histidyl ligated globin from Caenorhabditis elegans.
Biochemistry. 2010, 49, 5662-5670.


Ibrahim M, Derbyshire ER, Soldatova AV, Marletta MA, Spiro TG.

Soluble guanylate cyclase is activated differently by excess NO and by YC-1: Resonance Raman spectroscopic evidence.
Biochemistry. 2010, 49, 4864-4871.


Wang Y, Dufour YS, Carlson HK, Donohue TJ, Marletta MA, Ruby EG.

H-NOX-mediated nitric oxide sensing modulates symbiotic colonization by Vibrio fischeri.
Proc Natl Acad Sci USA. 2010, 107, 8375-8380.


Winter MB, McLaurin EJ, Reece SY, Olea C, Nocera DG, Marletta MA.

Ru-porphyrin protein scaffolds for sensing O2.
J Am Chem Soc. 2010, 132, 5582-5583.


Ibrahim M, Derbyshire ER, Marletta MA, Spiro TG.

Probing soluble guanylate cyclase activation by CO and YC-1 using resonance raman spectroscopy.
Biochemistry. 2010, 49, 3815-3823.


Woodward JJ, Nejatyjahromy Y, Britt RD, Marletta MA.

Pterin-centered radical as a mechanistic probe of the second step of nitric oxide synthase.
J Am Chem Soc. 2010, 132, 5105-5113.


Derbyshire ER, Deng S, Marletta MA.

Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.

J Biol Chem. 2010, 285, 17471-17478.


Olea C Jr, Herzik MA Jr, Kuriyan J, Marletta MA.

Structural insights into the molecular mechanism of H-NOX activation.
Protein Sci. 2010, 19, 881-887.


Carlson HK, Plate L, Price MS, Allen JJ, Shokat KM, Marletta MA.

Use of a semisynthetic epitope to probe histidine kinase activity and regulation.
Anal Biochem. 2010, 397, 139-143.


Tian C, Beeson WT, Iavarone AT, Sun J, Marletta MA, Cate JH, Glass NL.

Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa.
Proc Natl Acad Sci USA. 2009, 106, 22157-22162.


Weinert EE, Plate L, Whited CA, Olea C Jr, Marletta MA.

Determinants of ligand affinity and heme reactivity in H-NOX domains.
Angew Chem Int Ed Engl. 2010, 49, 720-723.


Fernhoff NB, Derbyshire ER, Marletta MA.

A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase.
Proc Natl Acad Sci USA. 2009, 106, 21602-21607.


Erbil WK, Price MS, Wemmer DE, Marletta MA.
A structural basis for H-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformation.
Proc Natl Acad Sci USA. 2009, 106, 19753-19760.


Agapie T, Suseno S, Woodward JJ, Stoll S, Britt RD, Marletta MA.

NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum.
Proc Natl Acad Sci USA. 2009, 106, 16221-16226.


Tran R, Boon EM, Marletta MA, Mathies RA.

Resonance raman spectra of an O2-binding H-NOX domain reveal heme relaxation upon mutation.
Biochemistry, 2009, 48, 8568-8577.


Niles JC, Derisi JL, Marletta MA.

Inhibiting Plasmodium falciparum growth and heme detoxification pathway using heme-binding DNA aptamers.
Proc Natl Acad Sci USA. 2009, 106, 13266-13271.


Derbyshire ER, Fernhoff NB, Deng S, Marletta MA.

Nucleotide regulation of soluble guanylate cyclase substrate specificity.
Biochemistry. 2009, 48, 7519-7524.


Reece SY, Woodward JJ, Marletta MA.

Synthesis of nitric oxide by the NOS-like protein from Deinococcus radiodurans: a direct role for tetrahydrofolate.
Biochemistry. 2009, 48, 5483-5491.


Zimmer M, Gray JM, Pokala N, Chang AJ, Karow DS, Marletta MA, Hudson ML, Morton DB, Chronis N, Bargmann CI.

Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases.
Neuron. 2009, 61, 865-879.


Martin NI, Woodward JJ, Winter MB, Marletta MA.

4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase.

Bioorg Med Chem Lett. 2009, 19, 1758-1762.


Woodward JJ, Chang MM, Martin NI, Marletta MA.

The second step of the nitric oxide synthase reaction: evidence for ferric-peroxo as the active oxidant.
J Am Chem Soc. 2009, 131, 297-305.


Derbyshire ER, Marletta MA..

Biochemistry of soluble guanylate cyclase.
Handb Exp Pharmacol. 2009, 191, 17-31.


Marletta MA, Stubbe J.

Catalysis and regulation. Editorial overview.
Curr Opin Struct Biol. 2008, 18, 641-643.


Winger, JW; Derbyshire, ER; Lamers, MH; Marletta, MA; Kuriyan, J.

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase.
BMC Struct Biol. 2008, 8, 42.


Olea, C; Boon, EM; Pellicena, P; Kuriyan, J; Marletta, MA.

Probing the function of heme distortion in the H-NOX family.
ACS Chem Biol. 2008, 3, 703-710.


Chao, LY; Rine, J; Marletta, MA.

Spectroscopic and kinetic studies of Nor1, a cytochrome P450 nitric oxide reductase from the fungal pathogen Histoplasma capsulatum.
Arch Biochem Biophys. 2008, 480, 132-137.


Chang, HH.; Falick, AM.; Carlton, PM.; Sedat, JW.; DeRisi, JL.; Marletta, MA.

N-terminal processing of proteins exported by malaria parasites.
Mol Biochem Parasitol. 2008, 160, 107-115.


Chao, LY.; Marletta, MA.; Rine, J.

Sre1, an iron-modulated GATA DNA-binding protein of iron-uptake genes in the fungal pathogen Histoplasma capsulatum.
Biochemistry. 2008, 47, 7274-783.


Derbyshire, ER; Gunn, A; Ibrahim, M; Spiro, TG.; Britt, RD; Marletta, MA.

Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes.
Biochemistry. 2008, 47, 3892-3899.


Martin, NI; Beeson, WT; Woodward, JJ; Marletta, MA.

NG-Aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors.
J Med Chem. 2008, 51, 924-931.


Mitchell, DA.; Michel, T; Marletta, MA.

Effects of S-nitrosation of nitric oxide synthase.
Adv Exp Biol. 2007, 1, 151-179.


Derbyshire, ER; Marletta, MA.

Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase: investigating the role of non-heme nitric oxide.
J Biol Chem. 2007, 282, 35741-35748.


Huang, SH; Rio, DC; Marletta, MA.

Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, Gyc-88E, from Drosophila.
Biochemistry. 2007, 46, 15115-15122.


Price, MS; Chao, LY; Marletta, MA.

Shewanella oneidensis MR-1 H-NOX regulation of a histidine kinase by nitric oxide.
Biochemistry. 2007, 46, 13677-13683.


Martin, NI; Woodward, JJ; Winter, MB; Beeson, WT; Marletta, MA.

Design and synthesis of C5 methylated L-Arginine analogues as active site probes for nitric oxide synthase.
J Am Chem Soc. 2007, 129, 12563-12570.


Martin, NI; Derbyshire, ER; Marletta, MA.

Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.
Bioorg Med Chem Lett. 2007, 17, 4938-4941.


Mitchell, DA; Morton, SU; Fernhoff, NB; Marletta, MA.

Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells.
Proc Nat Acad Sci USA. 2007, 104, 11609-11614.


Winger, JA; Derbyshire, ER; Marletta, MA.

Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs.
J Biol Chem. 2007, 282, 897-907.


Woodward, JJ; Martin, NI; Marletta, MA.

An Escherichia coli expression-based method for heme substitution.
Nat Methods. 2007, 4, 43-45


Mitchell, DA; Morton, SU; Marletta, MA.

Design and characterization of an active site selective caspase-3 transnitrosating agent.
ACS Chem Biol. 2006, 1, 659-665.


Niles, JC; Marletta, MA.

Utilizing RNA aptamers to probe a physiologically important heme-regulated cellular network.
ACS Chem Biol. 2006, 1, 515-524.


Marletta, MA.

Raising enzymes from the dead and the stories they tell.

ACS Chem Biol. 2006, 1, 73-74.


Martin, NI; Woodward, JJ; Marletta, MA.

NG-hydroxyguanidines from primary amines.
Org Lett. 2006, 8, 4035-4038.


Chang AJ; Chronis N; Karow DS; Marletta MA; Bargmann CI.

A distributed chemosensory circuit for oxygen preference in C. elegans.

PLoS Biol. 2006, 4, e274.


Boon, EM; Davis, JH; Tran, R; Karow, DS; Huang, SH; Pan, D; Miazgowicz, MM; Mathies, RA; Marletta, MA.

Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta1 H-NOX domain.
J Biol Chem. 2006, 281, 21892-21902.


Boon, EM.; Marletta, MA.

Sensitive and selective detection of nitric oxide using an H-NOX domain.
J Am Chem Soc. 2006, 128, 10022-10023.


Cary, SP; Winger, JA; Derbyshire, ER; Marletta, MA.

Nitric oxide signaling: no longer simply on or off.
Trends Biochem Sci. 2006, 31, 231-239.


Hering, KW; Artz, JD; Pearson, WH; Marletta, MA.

The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase.
Bioorg Med Chem Lett. 2006, 16, 618-621.


Karow, DS; Pan, D; Davis, JH; Behrends, S; Mathies, RA; Marletta, MA.

Characterization of functional heme domains from soluble guanylate cyclase.
Biochemistry. 2005, 44, 16266-16274.


Derbyshire, ER; Tran, R; Mathies, RA; Marletta, MA.

Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase.
Biochemistry. 2005, 44, 16257-16265.


Mitchell, DA; Marletta, MA.

Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine.
Nat Chem Biol. 2005, 1, 154-158.


Erwin, PA; Mitchell, DA; Sartoretto, J; Marletta, MA; Michel, T.

Subcellular targeting and differential S-nitrosylation of endothelial nitric oxide synthase.
J Biol Chem. 2005, 281, 151-157.


Mills, SA; Marletta, MA.

Metal binding characteristics and role of iron oxidation in the ferric uptake regulator from Escherichia coli.
Biochemistry. 2005, 44, 13553-13559.


Boon, EM; Marletta, MA.

Ligand discrimination in soluble guanylate cyclase and the H-NOX family of heme sensor proteins.
Curr Opin Chem Biol. 2005, 9, 441-446.


Boon, EM; Huang, SH; Marletta, MA.

A molecular basis for NO selectivity in soluble guanylate cyclase.
Nat Chem Biol. 2005, 1, 53-59.


Cary, SP; Winger, JA; Marletta, MA.

Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP.

Proc Natl Acad Sci USA. 2005, 102, 13064-13069.


Luzzi, SD; Marletta, MA.

L-arginine analogs as alternate substrates for nitric oxide synthase.
Bioorg Med Chem Lett. 2005, 15, 3934-3941.


Udit, AK; Belliston-Bittner, W; Glazer, EC; Nguyen, YH; Gillan, JM; Hill, MG; Marletta, MA; Goodin, DB; Gray, HB.

Redox couples of inducible nitric oxide synthase.
J Am Chem Soc. 2005, 127, 11212-11213.


Gribovskaja, I; Brownlow, KC; Dennis, SJ; Rosko, AJ; Marletta, MA; Stevens-Truss, R.

Calcium-binding sites of calmodulin and electron transfer by inducible nitric oxide synthase.
Biochemistry. 2005, 44, 7593-7601.


Boon, EM; Marletta, MA.

Ligand specificity of H-NOX domains: from sGC to bacterial NO sensors.
J Inorg Biochem. 2005, 99, 892-902.


Mitchell, DA; Erwin, PA; Michel, T; Marletta, MA.

S-Nitrosation and regulation of inducible nitric oxide synthase.
Biochemistry. 2005, 44, 4636-4647.


Winger, JA; Marletta, MA.

Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domain.
Biochemistry. 2005, 44, 4083-4090.


Schneider, EL; King, DS; Marletta, MA.

Amino acid substitution and modification resulting from Escherichia coli expression of recombinant Plasmodium falciparum histidine-rich protein II.

Biochemistry. 2005, 44, 987-995.


Schneider, EL; Marletta, MA.
Heme binding to the histidine-rich protein II from Plasmodium falciparum.
Biochemistry. 2005, 44, 979-986.


Pellicena, P; Karow, DS; Boon, EM; Marletta, MA; Kuriyan, J.
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases.
Proc Natl Acad Sci USA. 2004, 101, 12854-12859.


Karow, DS; Pan, D; Tran, R; Pellicena, P; Presley, A; Mathies, RA; Marletta, MA.
Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis.

Biochemistry. 2004, 43, 10203-10211.


Gray, JM; Karow, DS; Lu, H; Chang, AJ; Chang, JS; Ellis, RE; Marletta, MA; Bargmann, CI.
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.
Nature. 2004, 430, 317-322.


Miller, BH; Fratti, RA; Poschet, JF; Timmins, GS; Master, SS; Burgos, M; Marletta, MA; Deretic, V.
Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection.
Infect Immun. 2004, 72, 2872-2878.


Zhao, X; Miller, JR; Jiang, Y; Marletta, MA; Cronan, JE.
Assembly of the covalent linkage between lipoic acid and its cognate enzymes.
Chem Biol. 2003, 10, 1293-1302.


Hurshman, AR; Krebs, C; Edmondson, DE; Marletta, MA.
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity.

Biochemistry. 2003, 42, 13287-13303.


Spiering, MM; Ringe, D; Murphy, JR; Marletta, MA.
Metal stoichiometry and functional studies of the diphtheria toxin repressor.
Proc Natl Acad Sci USA. 2003, 100, 3808-3813.


Marletta MA; Spiering MM.

Trace elements and nitric oxide function.

J. Nutr. 2003, 133, 1431-1433S.


Ballou, DP; Zhao, Y; Brandish, PE; Marletta, MA.
Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: the simple NO-binding model is incorrect.
Proc Natl Acad Sci USA. 2002, 99, 12097-12101.


Choi, CY; Schneider, EL; Kim, JM; Gluzman, IY; Goldberg, DE; Ellman, JA; Marletta, MA.
Interference with heme binding to histidine-rich protein-2 as an antimalarial strategy.
Chem Biol. 2002, 9, 881-889.


Artz, JD; Schmidt, B; McCracken, JL; Marletta, MA.
Effects of nitroglycerin on soluble guanylate cyclase: implications for nitrate tolerance.
J Biol Chem. 2002, 277, 18253-18256.


Hurshman, AR; Marletta, MA.
Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer.
Biochemistry. 2002, 41, 3439-3456.

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