THE MARLETTA LABORATORY

Education:

 

• Ph.D. Chemistry - 2014
  University of Massachusetts at Amherst, MA
   

• B.S. Chemistry; B.S. Forensic Science - 2009
  University of New Haven, CT

   

   

   

   

   

   

   

 

University of California, Berkeley

356 Stanley Hall, Berkeley, CA 94720

 

Email: jhangasky<spAm>berkeley.edu

Phone: (510) 642-8766

 

Publications:

 

• Hangasky JA, Detomasi TC, Marletta MA. Glycosidic bond hydroxylation by polysaccharide monooxygenases. Trends in Chemistry 2019.

• Hangasky JA and Marletta MA. A random-sequential kinetic mechanism for polysaccharide monooxygenases. Biochemistry 2018.

• Hangasky JA, Iavorone AT, Marletta MA. Reactivity of O2 versus H2O2 with polysaccharide monooxygenases. Proc Natl Acad Sci 2018.

• Agostoni M, Hangasky JA, Marletta MA. Physiological and molecular understanding of bacterial polysaccharide monooxygenases. MMBR 81 2017.

• Hangasky JA, Taabazuing CY, Martin C, Eron S, Knapp MJ. The facial triad in the aKG oxygenase FIH: A role for sterics linking substrate binding to O2 activation. J Inorg Biochem 2017 Jan 166;26-33.

• Hangasky JA, Gandhi H, Valliere MA, Ostrom NE, Knapp MJ. The rate-limiting step of O2 activation in the α-ketoglutarate oxygenase factor inhibiting hypoxia inducible factor. Biochemistry. 2014 Dec 30;53(51):8077-84.

• Hangasky JA, Ivison GT, Knapp MJ. Substrate positioning by Gln(239) stimulates turnover in factor inhibiting HIF, an αKG-dependent hydroxylase. Biochemistry. 2014 Sep 16;53(36):5750-8.

• Taabazuing CY, Hangasky JA, Knapp MJ. Oxygen sensing strategies in mammals and bacteria. J Inorg Biochem. 2014 Apr;133:63-72.

• Light KM, Hangasky JA, Knapp MJ, Solomon EI. First- and second-sphere contributions to Fe(II) site activation by cosubstrate binding in non-heme Fe enzymes. Dalton Trans. 2014 Jan 28;43(4):1505-8.

• Light KM, Hangasky JA, Knapp MJ, Solomon EI. Spectroscopic studies of the mononuclear non-heme Fe(II) enzyme FIH: second-sphere contributions to reactivity. J Am Chem Soc. 2013 Jul 3;135(26):9665-74.

• Hangasky JA, Taabazuing CY, Valliere MA, Knapp MJ. Imposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases. Metallomics. 2013 Apr;5(4):287-301.

• Hangasky JA, Saban E, Knapp MJ. Inverse solvent isotope effects arising from substrate triggering in the factor inhibiting hypoxia inducible factor. Biochemistry. 2013 Mar 5;52(9):1594-602.

• Saban E, Chen YH, Hangasky JA, Taabazuing CY, Holmes BE, Knapp MJ. The second coordination sphere of FIH controls hydroxylation. Biochemistry. 2011 May 31;50(21):4733-40.

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