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Alejandra Martínez
Post-doctoral associate
Education:
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Ph.D. Biological Sciences, emphasis in Biochemistry - 2018 University of the Republic, Uruguay
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Clinical Biochemistry - 2011 University of the Republic, Uruguay
University of California, Berkeley
356 Stanley Hall, Berkeley, CA 94720
Email: amartinezdalto<spAm>berkeley.edu
Phone: (510) 642-8766
Pronouns: She/Her
Publications:
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Martínez A, Prolo C, Estrada D, Rios N, Alvarez MN, Piñeyro MD, Robello C, Radi R, Piacenza L. (2019) Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical. Proc. Natl. Acad. Sci. USA, 116(18):8879-8888.
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Estrada D, Specker G, Martínez A, Dias PP, Hissa B, Andrade LO, Radi R, Piacenza L. (2018) Cardiomyocyte diffusible redox mediators control Trypanosoma cruzi infection: role of parasite mitochondrial iron superoxide dismutase. Biochem. J., 475(7):1235-1251.
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Hugo M, Martínez A, Trujillo M, Estrada D, Mastrogiovanni M, Linares E, Augusto O, Issoglio F, Zeida A, Estrín DA, Heijnen HF, Piacenza L, Radi R. (2017) Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP). Proc. Natl. Acad .Sci. USA, 114(8):E1326-E1335.
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Rios N, Piacenza L, Trujillo M, Martínez A, Demicheli V, Prolo C, Álvarez MN, López GV, Radi R. (2016) Sensitive detection and estimation of cell-derived peroxynitrite fluxes using fluorescein-boronate. Free Radic. Biol. Med., 101:284-295.
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Martínez A, Peluffo G, Petruk AA, Hugo M, Piñeyro D, Demicheli V, Moreno DM, Lima A, Batthyány C, Durán R, Robello C, Martí MA, Larrieux N, Buschiazzo A, Trujillo M, Radi R, Piacenza L. (2014) Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intramolecular electron transfer. J. Biol. Chem., 289(18):12760-78.
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Piacenza L, Peluffo G, Alvarez MN, Martínez A, Radi R. (2013) Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease. Antioxid. Redox. Signal., 19(7):723-34.